Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.5
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
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8
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
8
We observed a compelling case involving a 19-year-old female diagnosed with cerebral venous thrombosis (CVT) and intracerebral hemorrhage. This unusual situation stemmed from her history of nitrous oxide abuse, which led to a significant deficiency in vitamin B12. Nitrous oxide can interfere with vitamin B12's vital functions, particularly its role in breaking down homocysteine levels in the blood.
Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.
This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.
Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.
Our investigation revealed her serum vitamin B12 level was alarmingly low at less than 100 pg/mL, while her homocysteine levels soared to 100.6 µmol/L, far exceeding the normal range. After she began vitamin B12 supplementation, we were pleased to see her vitamin B12 levels return to normal, along with a drastic reduction in homocysteine.
This case highlights an essential connection: low vitamin B12 levels may contribute to hyperhomocysteinemia, which in turn could play a significant role in the formation of blood clots. While there were no other thrombophilia risk factors found, the evidence suggests that restoring vitamin B12 levels through supplementation can positively impact homocysteine levels and reduce the risk of clotting problems.
Overall, this finding underscores how important vitamin B12 is in maintaining healthy blood clotting mechanisms.
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Most Useful Reviews
9
Maintained red blood cells
6 people found this helpful
I've taken this supplement for over eight years, and it helps maintain my hair and keeps my red blood cell count normal. Since starting, I've avoided anaemia, which is remarkable.
Read More
9
Improves blood count
5 people found this helpful
I started taking folic acid alongside iron and vitamin B complex to enhance my blood count. Although I dislike the need to take it with food, my blood health has improved significantly, as I’ve battled anaemia. It not only boosts metabolism but has helped me maintain my muscle while losing fat. I feel more energetic and much better overall. Highly recommend for quality ingredients!
Read More
9
Healthy blood maintenance
3 people found this helpful
Folic acid helps maintain healthy blood production and supports the formation of red and white blood cells.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.5
- All Researches
9
Supplementation improves health outcomes
We conducted a multi-center trial in Romania to explore how vitamin B12, folic acid, and vitamin D3 supplements could help lower homocysteine levels in Parkinson's disease patients on levodopa treatment.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
Over six months, we observed that participants who took these supplements experienced a significant reduction in homocysteine levels and an improvement in their overall quality of life.
The findings suggest that nutritional support can play a vital role in managing Parkinson's disease, potentially reducing risks associated with elevated homocysteine, such as blood clots and other complications.
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9
Vitamin B12 and blood clot relationship
We explored a case involving cerebral venous thrombosis (CVT) coinciding with hyperhomocysteinemia and iron-deficiency anemia, a condition attributed to autoimmune gastritis. The patient, a 47-year-old woman, presented with various symptoms including impaired movement and consciousness. Imaging tests revealed significant brain swelling and clot formations in the venous sinuses.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
Read More
9
We encountered a compelling case that sheds light on the relationship between vitamin B-12 deficiency and a condition known as pseudo-thrombotic microangiopathic anemia. This condition often mimics more severe blood disorders requiring aggressive treatments. However, during this case, we observed that addressing the deficiency with vitamin B-12 injections led to a significant improvement.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Read More
8
We explored a unique case of recurrent fainting after hysteroscopy, ultimately revealed as cerebral venous sinus thrombosis (CVST). This rare condition can mimic symptoms of more common complications like TURP syndrome, making diagnosis tricky.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Our patient, a 33-year-old woman, experienced multiple episodes of syncope and nausea shortly after her surgery. Administration of anticoagulants and folic acid, among other treatments, led to recovery. This case highlights the need for awareness of underlying vascular issues when typical surgery complications are ruled out.
Read More
8
We examined a unique case of cerebral venous thrombosis in a 14-year-old girl, associated with hyperhomocysteinemia and a rare mutation at the MTHFR locus. The patient displayed symptoms like headaches and nausea, with significantly elevated homocysteine levels.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 28 Reviews
7.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Maintained red blood cells
6 people found this helpful
I've taken this supplement for over eight years, and it helps maintain my hair and keeps my red blood cell count normal. Since starting, I've avoided anaemia, which is remarkable.
Read More
9
Improves blood count
5 people found this helpful
I started taking folic acid alongside iron and vitamin B complex to enhance my blood count. Although I dislike the need to take it with food, my blood health has improved significantly, as I’ve battled anaemia. It not only boosts metabolism but has helped me maintain my muscle while losing fat. I feel more energetic and much better overall. Highly recommend for quality ingredients!
Read More
9
Healthy blood maintenance
3 people found this helpful
Folic acid helps maintain healthy blood production and supports the formation of red and white blood cells.
Read More
7.5
Effective blood recovery
3 people found this helpful
After significant surgery and blood loss, my platelet count was dangerously low, and nothing helped for six months. My doctor recommended a combination of folic acid and vitamin B12. Within a month, my blood analysis showed improvement, and by three months, my platelets were normal again. Consistency in taking them is vital. Highly recommend!
Read More
9
Homocysteine reduction
1 people found this helpful
I purchased it to lower my blood homocysteine levels. After six months of use, my test results showed a threefold decrease, returning to normal levels! I will continue buying this supplement regularly!
Read More
Frequently Asked Questions
7.5
Effective blood recovery
3 people found this helpful
After significant surgery and blood loss, my platelet count was dangerously low, and nothing helped for six months. My doctor recommended a combination of folic acid and vitamin B12. Within a month, my blood analysis showed improvement, and by three months, my platelets were normal again. Consistency in taking them is vital. Highly recommend!
9
Homocysteine reduction
1 people found this helpful
I purchased it to lower my blood homocysteine levels. After six months of use, my test results showed a threefold decrease, returning to normal levels! I will continue buying this supplement regularly!
7.5
Immunity enhancement
46 people found this helpful
Folic acid is crucial for women as it aids in restoring immunity, strengthens blood vessels, positively impacts heart function, and promotes healthy hair and nails. I recommend it to women planning a pregnancy. The dosage is one tablet daily after meals. Don’t expect immediate results, but over time, the effects are certainly noticeable! Click "YES" if my review was helpful.
9
Maintained red blood cells
6 people found this helpful
I've taken this supplement for over eight years, and it helps maintain my hair and keeps my red blood cell count normal. Since starting, I've avoided anaemia, which is remarkable.
9
Improves blood count
5 people found this helpful
I started taking folic acid alongside iron and vitamin B complex to enhance my blood count. Although I dislike the need to take it with food, my blood health has improved significantly, as I’ve battled anaemia. It not only boosts metabolism but has helped me maintain my muscle while losing fat. I feel more energetic and much better overall. Highly recommend for quality ingredients!
8
Overall health improvement
1 people found this helpful
This folic acid supplement has greatly improved my well-being. It's an essential part of my regimen to aid cellular health and red blood cell production. The small, easy-to-swallow tablets and high quality, free from artificial additives, are definite perks. Since taking it, I feel much more energetic and healthier overall. I'd recommend it particularly for women of childbearing age.
0
Consult with doctor
10 people found this helpful
This particular combination of folic acid and vitamin B12 is making me very unwell. My blood rushes through my veins, and I feel flushed, resembling a heart attack. My husband can take these pills without any issues. My doctor informs me they are not suitable for everyone, so consulting with a doctor before taking them is advisable.
2
Potential risks involved
5 people found this helpful
This folic acid can pose problems if taken daily, particularly in higher doses. Folic acid needs to be processed in the liver, and if your body cannot convert it into its active form, you end up with unmetabolised folic acid in your bloodstream, which isn't ideal. It’s crucial to either stop using it and switch to folate or ensure adequate vitamin B levels for conversion. I advise using it less frequently and researching your supplement options.
7
We investigated how folic acid supplementation affects blood clots in patients with end-stage kidney disease (ESKD) undergoing hemodialysis. Our research used patient data from the Chang Gung Medical Foundation and compared daily versus weekly folic acid dosages.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
Interestingly, patients taking daily folic acid showed a lower rate of arteriovenous access thrombosis compared to those on weekly supplements. However, both groups had similar rates of other serious cardiovascular events, suggesting that while daily supplementation may help with thrombosis, it does not significantly impact overall cardiovascular health.
7
We examined the effects of serum folate and homocysteine on the occurrence of blood clots in patients with colorectal cancer. The study involved analyzing medical records of these patients, focusing on their serum folate and homocysteine levels, among other factors.
Our findings indicate that lower levels of folate were associated with a higher incidence of venous thromboembolism, a serious complication often seen in this patient group. Importantly, we observed that folate influences blood clot formation not directly, but rather through its relationship with homocysteine levels. This suggests that boosting folate could be a worthwhile strategy to manage homocysteine, potentially reducing the risk of blood clots.
Therefore, enhancing nutritional supplementation for these patients to maintain optimal serum folate and homocysteine levels could help mitigate the risk of developing venous thromboembolism. Overall, this research sheds light on the significant role that folate plays in blood clot dynamics among colorectal cancer patients.
Our findings indicate that lower levels of folate were associated with a higher incidence of venous thromboembolism, a serious complication often seen in this patient group. Importantly, we observed that folate influences blood clot formation not directly, but rather through its relationship with homocysteine levels. This suggests that boosting folate could be a worthwhile strategy to manage homocysteine, potentially reducing the risk of blood clots.
Therefore, enhancing nutritional supplementation for these patients to maintain optimal serum folate and homocysteine levels could help mitigate the risk of developing venous thromboembolism. Overall, this research sheds light on the significant role that folate plays in blood clot dynamics among colorectal cancer patients.
8
We examined a unique case of cerebral venous thrombosis in a 14-year-old girl, associated with hyperhomocysteinemia and a rare mutation at the MTHFR locus. The patient displayed symptoms like headaches and nausea, with significantly elevated homocysteine levels.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
After receiving a combination of anticoagulation therapy and supplementation with folate, B12, and B6, her condition improved remarkably over a month, reducing intracranial pressure and alleviating symptoms. This case emphasizes the importance of such genetic analysis in similar thrombotic cases.
2
We investigated how folate and other B-vitamins impact blood clot formation and breakdown in patients with coronary artery disease (CAD). Our large study included nearly 2,000 CAD participants who were given different combinations of folic acid and B-vitamins over 3.8 years as part of the Western Norway B-Vitamin Intervention Trial.
Despite our efforts, we found that folate treatment didn't lead to significant changes in important measures of blood clot functionality, specifically clot lysis time (CLT) and maximum absorbance (Absmax). These factors are critical for understanding how blood clots behave, especially in the context of cardiovascular events like heart attacks.
We observed that higher levels of certain metabolites like homocysteine thiolactone and cysteine were linked to worse outcomes, indicating that while folate did not improve CLT or Absmax, some sulfur-containing compounds might play a significant role in predicting heart risks. Overall, the lack of improvement from B-vitamin therapy sheds light on the complexity of nutrition’s role in heart health.
Despite our efforts, we found that folate treatment didn't lead to significant changes in important measures of blood clot functionality, specifically clot lysis time (CLT) and maximum absorbance (Absmax). These factors are critical for understanding how blood clots behave, especially in the context of cardiovascular events like heart attacks.
We observed that higher levels of certain metabolites like homocysteine thiolactone and cysteine were linked to worse outcomes, indicating that while folate did not improve CLT or Absmax, some sulfur-containing compounds might play a significant role in predicting heart risks. Overall, the lack of improvement from B-vitamin therapy sheds light on the complexity of nutrition’s role in heart health.
References
- Zhang Y, Ye H, Chen D, Yan G, Li Z, et al. Recurrent syncope after hysteroscopy finally diagnosed as cerebral venous sinus thrombosis: a case report. AJOG Glob Rep. 2025;5:100446. doi:10.1016/j.xagr.2025.100446
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. doi:10.3390/diagnostics14151609
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. doi:10.3390/nu14194162
- Chaloulis SK, Tsaousis KT. Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia. Cureus. 2021;13:e20782. doi:10.7759/cureus.20782
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. doi:10.3390/jcm11020394
- Meng Q, Li B, Huang N, Wei S, Ren Q, et al. Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential. J Hazard Mater. 2022;424:127354. doi:10.1016/j.jhazmat.2021.127354
- Cao Y, Yao T, Chen H, Liu H, Li C, et al. The association of serum folate and homocysteine on venous thromboembolism in patients with colorectal cancer: a cross-sectional study. Transl Cancer Res. 2023;12:125. doi:10.21037/tcr-22-2839
- Sikora M, Skrzydlewski P, Perła-Kaján J, Jakubowski H. Homocysteine thiolactone contributes to the prognostic value of fibrin clot structure/function in coronary artery disease. PLoS One. 2022;17:e0275956. doi:10.1371/journal.pone.0275956
- Hudson JL, Laura DM, Berrocal AM. CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE. Retin Cases Brief Rep. 2023;17:734. doi:10.1097/ICB.0000000000001283
- Mohamed Yile MEH, Berteau E, Ramdani N, Mouyen T, Ferrier N. Uncommon Thromboembolic Events in Young Adults: A Rare Cause Uncovered. Cureus. 2025;17:e76962. doi:10.7759/cureus.76962
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. doi:10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. doi:10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. doi:10.7759/cureus.41428
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. doi:10.1177/19714009221147224
- Landry I, Chowdhury T, Hussein S, Thomas L. Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia. Cureus. 2021;13:e20228. doi:10.7759/cureus.20228
